CHD@ZJU: a knowledgebase providing network-based research platform on coronary heart disease by Leihong Wu, Xiang Li, Jihong Yang, Yufeng Liu, Xiaohui Fan and Yiyu Cheng. (Database (2013) 2013 : bat047 doi: 10.1093/database/bat047)
From the webpage:
Abstract:
Coronary heart disease (CHD), the leading cause of global morbidity and mortality in adults, has been reported to be associated with hundreds of genes. A comprehensive understanding of the CHD-related genes and their corresponding interactions is essential to advance the translational research on CHD. Accordingly, we construct this knowledgebase, CHD@ZJU, which records CHD-related information (genes, pathways, drugs and references) collected from different resources and through text-mining method followed by manual confirmation. In current release, CHD@ZJU contains 660 CHD-related genes, 45 common pathways and 1405 drugs accompanied with >8000 supporting references. Almost half of the genes collected in CHD@ZJU were novel to other publicly available CHD databases. Additionally, CHD@ZJU incorporated the protein–protein interactions to investigate the cross-talk within the pathways from a multi-layer network view. These functions offered by CHD@ZJU would allow researchers to dissect the molecular mechanism of CHD in a systematic manner and therefore facilitate the research on CHD-related multi-target therapeutic discovery.
Database URL: http://tcm.zju.edu.cn/chd/
The article outlines the construction of CHD@ZJU as follows:
Figure 1.
Procedure for CHD@ZJU construction. CHD-related genes were extracted with text-mining technique and manual confirmation. PPI, pathway and drugs information were then collected from public resources such as KEGG and HPRD. Interactome network of every pathway was constructed based on their corresponding genes and related PPIs, and the whole CHD diseasome network was then constructed with all CHD-related genes. With CHD@ZJU, users could find information related to CHD from gene, pathway and the whole biological network level.
While assisted by computer technology, there is a manual confirmation step that binds all the information together.