Gaming for a Cure: Computer Gamers Tackle Protein Folding describes how over 57,000 “players” bested supercomputers:
Analysis shows that players bested the computers on problems that required radical moves, risks and long-term vision — the kinds of qualities that computers do not possess.
Distributed human contribution to massive information projects is a proven fact. (The reading programme of the OED is an earlier example.)
Can you make mapping large data sets into an interesting game?
For some clues, see: Foldit.